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Having addressed potency issues in 1972, John Topliss’s contribution to understanding bioavailability is also a classic. Bioavailability is a highly complex property covering absorption, metabolism, protein binding and excretion, nevertheless Topliss showed how a rational approach could be applied to attempt to predict classes of bioavailability. An area of considerable continuing interest.

“QSAR Model for Drug Human Oral Bioavailability” Yoshida & Topliss:  J. Med. Chem. 2000, 43, 2575-2585

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