Publications & Patents 2018-05-04T10:58:07+00:00

Accelerating the life sciences ecosystem

Publications & Patents

Accelerating the life sciences ecosystem

Publications

Publications

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

2000

1995-1999

MedChemica Publication by Year
Most highly cited indicated with ‡.

Patents

Patents

Preparation of 4-benzimidazolyl-2-morpholino-6-piperidinyl-4-pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorder

11. Preparation of 4-benzimidazolyl-2-morpholino-6-piperidinyl-4-pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorder Butterworth, Sam; Griffen, Edward Jolyon; Hill, George Beresford; Pass, Martin WO 2008032089 A1.

Preparation of 4-benzimidazolyl-6-morpholino-2-piperazinyl-pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorder

10. Preparation of 4-benzimidazolyl-6-morpholino-2-piperazinyl-pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorder Butterworth, Sam; Griffen, Edward Jolyon; Pass, Martin  WO 2008032060 A1.

Preparation of 4-benzimidazolyl-6-morpholino-2-piperidinyl-4-pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorder

9. Preparation of 4-benzimidazolyl-6-morpholino-2-piperidinyl-4-pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorder Butterworth, Sam; Griffen, Edward Jolyon; Pass, Martin WO 2008032091 A1.

Preparation of 6-benzimidazolyl-2-morpholino-4-(azetidine, pyrrolidine, piperidine, or azepine) pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorders

8. Preparation of 6-benzimidazolyl-2-morpholino-4-(azetidine, pyrrolidine, piperidine, or azepine) pyrimidine derivatives as PI3K and mTOR kinase inhibitors for the treatment of proliferative disorders Butterworth, Sam; Griffen, Edward Jolyon; Hill, George Beresford; Pass, Martin WO 2008032036 A1.

Preparation of pyrimidine derivatives for treating proliferative disorders sensitive to inhibition of PI3K and/or mTOR kinase.

7. Preparation of pyrimidine derivatives for treating proliferative disorders sensitive to inhibition of PI3K and/or mTOR kinase. Butterworth, Sam; Griffen, Edward Jolyon; Pass, Martin WO 2008032077 A1.

Preparation of pyrimidine derivatives having inhibitory activity against PI3K enzymes

6. Preparation of pyrimidine derivatives having inhibitory activity against PI3K enzymes Butterworth, Sam; Griffen, Edward Jolyon; Pass, Martin  WO 2008032064 A1.

Preparation of pyrimidine derivatives having inhibitory activity against PI3K enzymes

5. Preparation of pyrimidine derivatives having inhibitory activity against PI3K enzymes Butterworth, Sam; Griffen, Edward Jolyon; Pass, Martin WO 2008032041 A1.

Pyrimidine derivatives as antiproliferative agents and their preparation, pharmaceutical compositions and use in the treatment of diseases

4. Pyrimidine derivatives as antiproliferative agents and their preparation, pharmaceutical compositions and use in the treatment of diseases  Butterworth, Sam; Griffen, Edward Jolyon; Hill, George Beresford; Pass, Martin WO 2008032027 A1.

Indole derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as inhibitors of PI3K and /or mTOR kinase

3. Indole derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as inhibitors of PI3K and /or mTOR kinase  Foote, Kevin Michael; Griffen, Edward Jolyon WO 2007135398 A1.

Preparation of thiazole derivatives as antitumor agents

2. Preparation of thiazole derivatives as antitumor agents Arnould, Jean-Claude; Foote, Kevin Michael; Griffen, Edward Jolyon WO 2007129044 A1.

Preparation of 5-heteroaryl thiazoles and their use as phosphoinositide 3-kinase (PI3K) inhibitors

1. Preparation of 5-heteroaryl thiazoles and their use as phosphoinositide 3-kinase (PI3K) inhibitors Bengtsson, Malena; Larsson, Joakim; Nikitidis, Grigorios; Storm, Peter; Bailey, John, Peter; Griffen, Edward, Jolyon; Arnould, Jean-Claude; Bird, Thomas, Geoffrey, Colerick WO 2006051270 A1.

Conference Talks

Conference Talks