Data Exploration
pMMPA
Permutative Matched Molecular Pair Analysis
Use Matched Pairs to determine SAR, then generate all permutations.
A module within the MCPairs platform.
How pMMPA Works
Your Matched Pairs in Four Steps
Input Compound
Submit a file of compounds.
Find Matched Pairs
Access to MedChemica pair finding algorithms – Fully configurable.
Find Rules
Identify key transformations that are frequent and reliable.
Export Results
Export promising compounds and continue your workflow in MCPairs.
How pMMPA Works
Explore the unrealised potential of your series
Use Matched Pairs to determine SAR, then generate all permutations.
Maximise SAR Knowledge
Complements Free-Wilson approaches by using chemical transformations
Coverage
Check and verify SAR and spot transformations that would have been missed.
Cross Check And Validate
Ideal for late LI and LO to ‘make all the permutations’.
Explore pMMPA
Has Anything Been Missed?
Find All The SAR
Matched pair analysis find the key SAR.
Generate New Compounds
Comprehensively use the SAR to generate new compounds.
Additive Potency Predictions
Uses the basic med chem principle that SAR transfers.
