MedChem Paper of the Month – Feb 2025
MedChemica2026-08-11T12:55:12+00:00A covalent chemical probe for Chikungunya nsP2 cysteine protease with anti-alphaviral activity and proteome-wide selectivity Sci.
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Comp. Chem. Paper of the Month – Feb 2025
MedChemica2026-08-11T12:55:12+00:00Real-World Applications and Experiences of AI/ML Deployment for Drug Discovery After listening to Rob
Comp. Chem. Paper of the Month – Jan 2025
MedChemica2026-08-11T12:55:12+00:00Faster Sampling in Molecular Dynamics Simulations with TIP3P-F Water A significant challenge for using
MedChem Paper of the Month – Jan 2025
MedChemica2026-08-11T12:55:12+00:00Discovery of Rezatapopt (PC14586), a First-in-Class, Small-Molecule Reactivator of p53 Y220C Mutant in Development
The Story of Zoliflodacin – A MedChemica Review
MedChemica2026-08-11T12:55:12+00:00Figure 1: The Structure of zoliflodacin Introduction Zoliflodacin (Figure 1, above) is
Comp. Chem. Paper of the Month – Nov 2024
MedChemica2026-08-11T12:55:12+00:00Estimating the synthetic accessibility of molecules with building block and reaction-aware SAScore JCIM. 2024.
MedChem Paper of the Month – Nov 2024
MedChemica2026-08-11T12:55:13+00:00Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators Med. Chem.2024, 67, 14432-14442 Coenzyme
MedChem paper of the month – Oct 2024
MedChemica2026-08-11T12:55:13+00:00N‐Substituted Pyrrole-Based Heterocycles as Broad-Spectrum Filoviral Entry Inhibitors J. Med. Chem.2024, 67, 13737-13764
Comp. Chem. Paper of the month – Oct 2024
MedChemica2026-08-11T12:55:13+00:00Prediction of Inhibitory Activity against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine
MedChem paper of the month – Sept 2024
MedChemica2026-08-11T12:55:13+00:00Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment Wei Long et
