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About Ed Griffen

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So far Ed Griffen has created 17 blog entries.

Covid Moonshot receives funding to advance compounds

2021-09-28T18:37:31+00:00

The Covid Moonshot project, to find a novel drug treatment for Covid-19s received a huge boost today of £8 million of support funding from the WellcomeTrust, on behalf of the Covid-19 Therapeutics Accelerator. The grant will aid the project to continue its work, driving to the clinic to find an effective, cheap and available drug.

Covid Moonshot receives funding to advance compounds2021-09-28T18:37:31+00:00

Dr Ed Griffen describes the medicinal chemistry of Covid Moonshot at Cambridge

2021-09-15T10:00:12+00:00

Leading the Medicinal Chemistry on the COVID Moonshot:  A refelection by Dr Ed Griffen Back at the start of the COVID-19 pandemic we were invited to join the COVID Moonshot project. It’s a self starting  open science academic-industrial collaboration.  The foundation was rapid fragment screening at the Diamond facility in Oxford, biochemistry from the Weizmann

Dr Ed Griffen describes the medicinal chemistry of Covid Moonshot at Cambridge2021-09-15T10:00:12+00:00

MedChemica – Med Chem paper of the Month – September 2021

2021-09-14T14:00:44+00:00

The rise and rise of protein degradation: Opportunities and challenges ahead Ian Churcher and colleagues, Amphista Therapeutics Ltd, Drug Discovery Today 20 August 2021, https://doi.org/10.1016/j.drudis.2021.08.006 Targeted protein degradation(TBD) has been one of the emerging approaches of the early 21st century particularly as unlike downregulation approaches which have the same conceptual advantage of reducing the amount

MedChemica – Med Chem paper of the Month – September 20212021-09-14T14:00:44+00:00

MedChemica – Comp Chem paper of the month – September 2021

2021-09-14T13:04:28+00:00

Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 1: Ways to make an impact, and why we are not there yet Drug Discovery Today. 2021, 26, 2, 511-524 https://doi.org/10.1016/j.drudis.2020.12.009 Artificial intelligence (AI) is having a moment in the limelight, but what does this mean in the field of drug discovery? In

MedChemica – Comp Chem paper of the month – September 20212021-09-14T13:04:28+00:00

MedChemica starts the Bucket list rolling again

2021-09-14T12:55:20+00:00

Welcome back to Bucket List Papers Sometime ago we started regularly posting what we think are the 100 must read papers computational and medicinal chemistry papers.  This was the “Bucket list”, which was updated at a rate of two papers a week until we got too busy last year. So apologies for the gap of

MedChemica starts the Bucket list rolling again2021-09-14T12:55:20+00:00

MedChemica is 9 years old and we are starting our eNewsletter

2021-09-13T12:42:12+00:00

Managing Director Dr Al Dossetter talks about 9 years in business and launching our e-newsletter... Where did nine years go? I am not going to describe ‘how we built the company?’, but more of where did that last 9 years go and what did we learn? It seems like a blur looking back and the

MedChemica is 9 years old and we are starting our eNewsletter2021-09-13T12:42:12+00:00

Covid Moonshot – Nature reviews covers the journey so far…

2021-06-14T10:32:06+00:00

Open source Drug Discovery https://www.nature.com/articles/d41586-021-01571-1 From the start of Covid Moonshot the team made all of the research data publicly available. This is a rare thing in life sciences, where protection of intellectual property is key to eventual returns on investment. During the first lockdown, and subsequent research efforts, this yielded a huge response from

Covid Moonshot – Nature reviews covers the journey so far…2021-06-14T10:32:06+00:00

MCPairs v1.7.2 released

2021-05-01T14:31:51+00:00

Additional methods of presenting the results. For RuleDesign(R) we have added two addition methods of looking at the suggest molecules: A lightweight view: So it is possible to view the results in browser and sort on just one of the data types that led to the suggestion being made. In the above example it is

MCPairs v1.7.2 released2021-05-01T14:31:51+00:00

MCPairs v1.7 released

2021-02-01T14:09:10+00:00

The MyPairs system with Permutative Matched Molecular Pair Analysis This year's release of MCPairs includes a new suite of tools for Matched Molecular Pair Analysis (MMPA). We were asked to expand our large scale database processing capability to allow smaller scale input files to be uploaded, processed on their own and returned to the user.

MCPairs v1.7 released2021-02-01T14:09:10+00:00

Covid Moonshot – first publication of progress so far

2020-10-30T08:50:41+00:00

From fragments to leads... At the start of the pandemic a team at Oxford University crystallised and performed a fragment screen in record time before the first lockdown started. They then posted the results on-line, thinking maybe they would get a bit of input from the global chemistry community. The outcome was a tidal wave

Covid Moonshot – first publication of progress so far2020-10-30T08:50:41+00:00
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