Comp. Chem. Paper of the Month – June 2022
Al Dossetter2022-06-16T10:39:15+00:00Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors In this article from the Institute for Cancer Research, binders of B-cell lymphoma 6 protein were sought. Previous work showed that there was potential hydrophobic pocket adjacent to the lead series and careful work to fill this pocket was pursued. Initial approaches considered fused