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About Al Dossetter

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So far Al Dossetter has created 20 blog entries.

Good to be attending conferences again.

2022-04-11T14:07:34+00:00

With a successful vaccine roll out and boasters jabs in the UK, the first full in person conferences have been taking place again. In the last two weeks I have attended two; of course, the virus does know about conferences so I was still wearing a face mask, even though the restrictions have been lifted.

Good to be attending conferences again.2022-04-11T14:07:34+00:00

Med Chem Paper of the Month – April 2022

2022-04-08T13:27:22+00:00

Small Molecule CNS compounds for neuropathic pain "In general, neuropathic pain conditions are under-recognized, underdiagnosed, and undertreated." The challenge to treating this disease is finding a safe, brain penetrating small molecule that effects the root cause. AAK1 show promise as a target, and this paper show the progress of a series of bi-aryl compounds. CNS

Med Chem Paper of the Month – April 20222022-04-08T13:27:22+00:00

Comp. Chem. Paper of the Month – April 2022

2022-04-09T16:39:20+00:00

Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki−Miyaura Coupling In this provocative study from the University of Illinois and Allchemy Inc, the ability of machine learning methods to predict the optimal conditions for some Suzuki-Miayaura couplings has been tested and compared to simply the most popular methods according

Comp. Chem. Paper of the Month – April 20222022-04-09T16:39:20+00:00

Green Commuting and feeling amazing.

2022-04-07T15:48:51+00:00

I guess I am blessed, I only live 7 miles from work. Back in the days of working for large pharma I was never satisfied with my carbon footprint. We used to have a bus service from Bollington [Cheshire, UK] and would take that each day for two years, but with just 14 or so

Green Commuting and feeling amazing.2022-04-07T15:48:51+00:00

Covid-Moonshot – Personal stories from scientists in Ukraine

2022-03-14T08:32:36+00:00

We know many biotechs and pharmaceutical companies work with Enamine to discovery small molecule drugs. They have played a key role in Covid Moonshot. Here are recent interviews, and news reports, from key scientists at Enamine in Ukraine, and the wider Moonshot team. Ukraine War Hobbles Covid-Pill Project in Lab Near Front Lines Based in

Covid-Moonshot – Personal stories from scientists in Ukraine2022-03-14T08:32:36+00:00

How War in Ukraine Affects Drug Discovery – Covid Moonshot

2022-03-08T11:58:29+00:00

Dr Ed Griffen has given an interview to The Medicine Maker about the effect of the current conflict in Ukraine on the Covid Moonshot project. https://themedicinemaker.com/discovery-development/we-want-to-return-to-the-lab-how-the-russian-invasion-has-disrupted-drug-discovery-in-ukraine

How War in Ukraine Affects Drug Discovery – Covid Moonshot2022-03-08T11:58:29+00:00

Hot news from MedChemica and the COVID Moonshot Team…

2022-02-15T11:36:38+00:00

Leading compounds meet the criteria: The COVID Moonshot announced last week a significant milestone in its journey towards an open-science COVID antiviral: We have identified compounds meeting our criteria for progression to preclinical evaluation! The story so far is captured in the updated biorxiv preprint: Mpro is validated but... Mpro is validated as a target

Hot news from MedChemica and the COVID Moonshot Team…2022-02-15T11:36:38+00:00

Comp Chem paper of the month – February 2022

2022-02-15T13:42:20+00:00

In this study, researchers from Boston College develop and then apply a boronic acid with appended carbonyl warhead that can target lysine for covalent binding. Formation of an imine is first facilitated by the boronic acid and the resulting imine forms a stable but reversible B-N interaction. The effect of the whole is to create

Comp Chem paper of the month – February 20222022-02-15T13:42:20+00:00

Towards MCPairs v1.8 – Depicting Aligned R-Groups with OpenEye Toolkits.

2022-02-12T16:49:41+00:00

In the course of our work towards an automated Structure Activity Relation (SAR) analysis system that’s intuitive for medicinal chemists to use, we needed to depict R-Groups on our web interface in an aligned manner. We use #OpenEyeScientific chemistry toolkits for our production servers as the speed, quality, and reliability is high. The challenge is

Towards MCPairs v1.8 – Depicting Aligned R-Groups with OpenEye Toolkits.2022-02-12T16:49:41+00:00

Med Chem paper of the Month – February 2022

2022-02-15T13:41:46+00:00

The January issue of J. Med. Chem is a bumper issue focussed on kinase inhibitors (January 27, 2022, Volume 65, Issue 2). Just about all of the papers are worthy of reading. It is likely you have already downloaded and seen it, but the review of small molecule kinase inhibitors looks to be the winner.

Med Chem paper of the Month – February 20222022-02-15T13:41:46+00:00
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