In compound design, and particularly drug design, the concept of lipophilicity is key. A measured partition co-efficient between water and octanol serves as a predictor of further properties and drug developability. Leo, Hansch and Elkins set out to compile multiple measurements from the literature to form the basis of further understanding of molecules interacting with biological systems. Without this “ClogP”, a computer calculated value we take for granted so much, would not exist. A job very well done.

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“Partition Coefficients and their Uses”: Leo, Hansch and Elkins:

Chem Rev. 1971;71(6):525–616

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