In molecular design we often refer to key ‘groups’ in our current best molecules and their effects. The concept of an isostere is a group that can replace another in molecular and retain most if not all of the properties. Better still is to improve one or two properties and keeping everything else the same.

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“Isosterism and molecular modification in drug design”, Thornbar

Chem. Soc. Rev., 1979,8, 563-580

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