The combinatorial chemistry and HTS boom of the 1990’s led to some shocking compounds being put into development. Analysis of their failure identified pharmacokinetics as a key issue. After the publication of Lipinski’s work, a number of other group turned to analysing their own ADME datasets asking the question :“what are the molecular properties of compounds with good and bad bioavailability” with the hope of designing in better pharmacokinetics.
“Molecular Properties That Influence the Oral Bioavailability of Drug Candidates”
For a retrospective on the properties of oral drugs and their analysis 20 years on, Shultz’s recent mini review gives another perspective:
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