Fast calculation of hydrogen-bond strengths and free energy of hydration of small molecules For

Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of

Med Chem Paper of the Month – Jan/Feb 2023 This paper is a fine exhibition

    A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery

Exposing the Limitations of Molecular Machine Learning with Activity Cliffs J. Chem. Inf. Model.

Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors This month’s paper

Boosting Protein−Ligand Binding Pose Prediction and Virtual Screening Based on Residue−Atom Distance Likelihood Potential

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306 This med chem paper

There be Rings in them Drugs This month, we choose to highlight a paper