ChEMBL29 - latest data... We have just completed our update of our core databases of med chem knowledge that runs at the heart of MCPairs Online. New compounds, data and assays have been added from the ChEMBL 29 database. There are nearly 9000 datasets and new rules for many of them. If you find a

Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor Barbara Czako and colleaugues, IACS (Institute for Applied Cancer Science), University of Texas MD Anderson Cancer Center, Houston J. Med. Chem. 2021, 64, 20, 15141–15169 Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2) has been an interesting target for small molecule inhibitors for the