MedChemica Logo

Tel: +44 (0)1625 238843

MedChemica Logo
MedChemica Logo

Strategies to Mitigate CYP450 Inhibition

2021-11-26T11:37:34+00:00

Strategies to Mitigate CYP450 Inhibition From the book: The Medicinal Chemist’s Guide to Solving ADMET Challenges Alexander G. Dossetter, Marcel J. de Groot and Sarah E. Skerratt https://pubs.rsc.org/en/content/chapter/bk9781788012270-00220/978-1-78801-227-0

Strategies to Mitigate CYP450 Inhibition2021-11-26T11:37:34+00:00

Small molecule Son of Sevenless 1 (SOS1) inhibitors:

2021-11-26T11:37:21+00:00

Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review of the patent literature Severin K. Thompson, Andreas Buckl, Alexander G. Dossetter, Ed Griffen & Adrian Gill Expert Opinion on Therapeutic Patents, 31(12), 2021, 1189-1204.  A comprehensive review of the patent published with claims for SOS1 inhibitors. An analysis of the spread of simple properties

Small molecule Son of Sevenless 1 (SOS1) inhibitors:2021-11-26T11:37:21+00:00

Mapping Ligand-Shape Space for Protein–Ligand Systems

2021-03-23T11:33:12+00:00

Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins Joanna Zarnecka, Iva Lukac, Stephen J. Messham, Alhusein Hussin, Francesco Coppola, Steven J. Enoch, Alexander G. Dossetter, Edward J. Griffen, and Andrew G. Leach*  J. Chem. Inf. Model. 2021, 61, 4, 1859–1874 March 23, 2021 https://doi.org/10.1021/acs.jcim.1c00089

Mapping Ligand-Shape Space for Protein–Ligand Systems2021-03-23T11:33:12+00:00

Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and Artificial Intelligence?

2018-05-03T11:09:15+00:00

Edward J.Griffen, Alexander G.Dossetter, Andrew G.Leach, Shane Montague, Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and artificial intelligence? Drug Discovery Today, online 22 March 2018 https://doi.org/10.1016/j.drudis.2018.03.011  

Can we accelerate medicinal chemistry by augmenting the chemist with Big Data and Artificial Intelligence?2018-05-03T11:09:15+00:00

Turbocharging Matched Molecular Pair Analysis

2018-01-18T17:11:49+00:00

Lukac I, Zarnecka J, Griffen EJ, Dossetter AG, St-Gallay SA, Enoch SJ, et al. Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs. J Chem Inf Model 2017;57:2424–36. http://dx.doi/10.1021/acs.jcim.7b00335

Turbocharging Matched Molecular Pair Analysis2018-01-18T17:11:49+00:00

WizePairZ: A Novel Algorithm to Identify, Encode, and Exploit Matched Molecular Pairs with Unspecified Cores in Medicinal Chemistry

2017-11-07T14:36:08+00:00

59) WizePairZ: A Novel Algorithm to Identify, Encode, and Exploit Matched Molecular Pairs with Unspecified Cores in Medicinal Chemistry Daniel J. Warner, Edward J. Griffen and Stephen A. St-Gallay J. Chem. Inf. Model., 2010, 50 (8), pp 1350–1357 Publication Date (Web): August 6, 2010 (Article) DOI: 10.1021/ci100084s

WizePairZ: A Novel Algorithm to Identify, Encode, and Exploit Matched Molecular Pairs with Unspecified Cores in Medicinal Chemistry2017-11-07T14:36:08+00:00

A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series

2017-11-07T14:35:27+00:00

60) A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series. Dossetter, Alexander G. Bioorganic & Medicinal Chemistry (2010), 18(12), 4405-4414.

A statistical analysis of in vitro human microsomal metabolic stability of small phenyl group substituents, leading to improved design sets for parallel SAR exploration of a chemical series2017-11-07T14:35:27+00:00
Go to Top