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“The Discovery of Benzanilides as c-Met Receptor Tyrosine Kinase Inhibitors by a Directed Screening approach”

2017-11-07T14:33:54+00:00

62) “The Discovery of Benzanilides as c-Met Receptor Tyrosine Kinase Inhibitors by a Directed Screening approach” Allen, J. V.; Bardelle, C.; Blades, K.; Buttar, D.; Chapman, L.; Colclough, N.; Dossetter, A. G.; Garner, A. P.; Girdwood, A.; Lambert, C.; Leach, A. G.; Law, B.; Major, J.; Plant, H.; Slater, A. M. Bioorganic & Medicinal Chemistry

“The Discovery of Benzanilides as c-Met Receptor Tyrosine Kinase Inhibitors by a Directed Screening approach”2017-11-07T14:33:54+00:00

“Discovery, optimisation and in vivo evaluation of novel GPR119 agonists”

2017-11-07T14:32:25+00:00

64) “Discovery, optimisation and in vivo evaluation of novel GPR119 agonists” Brocklehurst, K. J.; Broo, A.; Butlin, R. J.; Brown, H. S.; Clarke, D. S.; Davidsson, Ö.; Goldberg, K.; Groombridge, S. D.; Kelly, E. E.; Leach, A.; McKerrecher, D.; O’Donnell, C.; Poucher, S.; Schofield, P.; Scott, J. S.; Teague, J.; Westgate, L.; Wood, M. J.

“Discovery, optimisation and in vivo evaluation of novel GPR119 agonists”2017-11-07T14:32:25+00:00

DNA-dependent protein kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain

2017-11-07T14:31:41+00:00

65) DNA-dependent protein kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain Clapham, Kate M.; Bardos, Julia; Finlay, M. Raymond V.; Golding, Bernard T.; Griffen, Edward J.; Griffin, Roger J.; Hardcastle, Ian R.; Menear, Keith A.; Ting, Attilla; Turner, Paul;  et al  Bioorganic & Medicinal Chemistry Letters (2011), 21(3), 966-970.DOI: 10.1016/j.bmcl.2010.12.047

DNA-dependent protein kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain2017-11-07T14:31:41+00:00

“Do Glycosyl Sulfonium Ions Engage in Neighbouring-Group Participation? A Study of Oxathiane Glycosyl Donors and the Basis for their Stereoselectivity”

2017-11-07T14:30:54+00:00

66) “Do Glycosyl Sulfonium Ions Engage in Neighbouring-Group Participation? A Study of Oxathiane Glycosyl Donors and the Basis for their Stereoselectivity” Fascione, M. A.; Kilner, C. A.; Leach, A. G.; Turnbull, W. B. Chem. Eur. J. 2012, 18, 321-333.

“Do Glycosyl Sulfonium Ions Engage in Neighbouring-Group Participation? A Study of Oxathiane Glycosyl Donors and the Basis for their Stereoselectivity”2017-11-07T14:30:54+00:00

“Mechanistic Studies on a Sulfoxide Transfer Reaction Mediated by Diphenyl Sulfoxide/Triflic Anhydride”

2017-11-07T14:29:49+00:00

67) “Mechanistic Studies on a Sulfoxide Transfer Reaction Mediated by Diphenyl Sulfoxide/Triflic Anhydride” Fascione, M. A.; Adshead, S. J.; Mandal, P. K.; Kilner, C. A.; Leach, A. G.; Turnbull, W. B. Chem. Eur. J. 2012, 18, 2987-2997.

“Mechanistic Studies on a Sulfoxide Transfer Reaction Mediated by Diphenyl Sulfoxide/Triflic Anhydride”2017-11-07T14:29:49+00:00

Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain

2017-11-07T14:29:05+00:00

68) Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain Andrew G. Leach, Elizabeth A. Pilling, Alfred A. Rabow, Simone Tomasi, Nabil Asaad, Niklaas J. Buurma, Andrew Ballard and Stefania Narduolo Med. Chem. Commun., 2012,3, 528-540.

Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain2017-11-07T14:29:05+00:00

Oxadiazole isomers: all bioisosteres are not created equal

2017-11-07T14:28:35+00:00

69) Oxadiazole isomers: all bioisosteres are not created equal Kristin Goldberg, Sam Groombridge, Julian Hudson, Andrew G. Leach, Philip A. MacFaul, Adrian Pickup, Ruth Poultney, James S. Scott, Per H. Svensson and Joseph Sweeney Med. Chem. Commun., 2012,3, 600-604.

Oxadiazole isomers: all bioisosteres are not created equal2017-11-07T14:28:35+00:00
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